- Peptides (5)
- Knee (66)
- Back & Spine (4)
- Shoulder & Rotator Cuff (31)
- Hip (11)
- Hand, Wrist & Elbow (12)
- Platelet-Rich Plasma (PRP) (91)
- Bone Marrow Concentrate & Stem Cells (96)
- Ultrasound-Guided Care & Needle Arthroscopy (17)
- FDA Rules, Exosomes & Stem Cell Scams (72)
- Research, Evidence & Publications (78)
What Your PRP Dose Actually Was — and Why Nobody Told You
Three randomized trials injected the same 5cc into the same kind of knee on the same weekly schedule. Two found nothing. One is still working at five years. The variable was dose — and now...
Amniotic Stem Cell Injections in Dallas: What Is Actually in the Vial
If you have searched for a stem cell injection in Dallas you have been offered an amniotic or umbilical cord product. Here is what is actually in it, what the FDA has said about it since...
Can Stem Cells Help You Avoid Knee Replacement? What 15 Years of Research Shows
If knee arthritis has you weighing a knee replacement, there may be a middle path. Using your own body's repair cells, BMAC therapy helped most patients keep their natural knee at 15 years...
Orthopedic Regenerative Medicine in Dallas: PRP, Bone Marrow Concentrate, and Nonsurgical Joint Pain Treatment
Orthopedic regenerative medicine offers patients a nonsurgical approach to treating arthritis, tendon injuries, ligament injuries, and certain spine conditions using advanced treatments...
PRP & Stem Cell Clinic Serving Plano, Frisco, McKinney & Dallas | Dr. Don Buford
Not all PRP clinics in Dallas are equal — and the differences matter. I'm Dr. Don Buford, a board-certified orthopedic surgeon and President of the Interventional Orthobiologics...
The Truth About Peptides, Compounding Pharmacies, and FDA Regulation
Patients are hearing wildly different claims about peptides like BPC-157, TB-500, and GHK-Cu. Some clinics say they are legal. Others say they are banned. So what is actually true? In this...
Frozen Shoulder Treatment: Why Most Approaches Fail (and What Actually Works)
Frozen shoulder is often treated as a simple shoulder problem—but that approach frequently leads to prolonged pain and slow recovery. Learn why most treatments fail and what actually works...
Peptides Versus PRP For Orthopedic Problems...which is better?
Why try peptides like BP-157 and TB-500 for orthopedic problems when we know that high dose PRP is better?*
Have You Heard About Using Exosomes For Knee Arthritis?
In 2024 a research group in Iran did a well designed and controlled trial comparing 5cc of placental derived exosomes with 5cc of normal saline. 29 Patients were followed for six...
What Does A World Class PRP and Stem Cell and Orthopedic Surgery Clinic Look Like?
Texas Orthobiologics is your PRP (platelet rich plasma) expert and your stem cell (bone marrow concentrate) expert AND your orthopedic surgery expert all in one Dallas location! Don...
What do the World Series and PRP (Platelet Rich Plasma) have in common? Value!
This picture shows ticket prices for an upcoming World Series game between the Dodgers and Blue Jays. For 2 people to go, it costs more than the average price for single PRP...
What is the real deal on BP-157 research in humans?
Are there any safety or placebo trials registered for the peptide BP-157? I get this question often from clinicians and patients ask me what I mean when I say there is no human safety...
Don Buford / Texas Orthobiologics' Regenerative Medicine Research Is Growing!
Every 6 months or so I like to update my list of publications which include articles, book chapters, letters to the editor, and other references. My first co-authored paper, "The Buford...
The Las Vegas Regenerative Medicine and MSK Ultrasound Course - January 8-10, 2026
*The Las Vegas Regenerative Medicine and MSK Ultrasound Course* *January 8-10, 2026 Virgin Hotel, Las Vegas* We are back for our 18th year! Hotel rooms in our block are $169 with NO resort...
Have You Been Offered Prolozone or Ozone Therapy In The USA? We Can't Do That Right Now...says the FDA!
The Problem? There are no approved medical ozone devices or ozone therapies for ANY medical condition in the USA....so says the only regulatory authority....the FDA. So, any clinic or...
Regenerative Medicine, PRP, and Stem Cells In Mexico!
There is a great orthopedic meeting going on right now in Acapulco, Mexico! This is the 29th annual AMECRA meeting which is an international meeting focused on arthroscopy and arthroplasty...
Stem Cell Injections For Hand Arthritis...Do They Work?
Can a stem cell (bone marrow concentrate) injection outperform a PRP injection in the small joints of the hand/wrist? It's a question I often get asked.....with such a small volume...
What is a frozen shoulder? Do you have one?
A frozen shoulder is simply a shoulder that does not have normal motion. Usually a frozen shoulder is painful, especially when the limits of the range of motion are reached. The most...
Bringing the latest regenerative medicine and ultrasound training to orthopedic surgeons
Regenerative medicine and ultrasound use are growing within orthopedics! Last month at the 2025 annual Arthroscopy Association Of North America meeting (AANA) I lectured on regenerative...
What you need to know about regenerative medicine in orthopedics!
At Texas Orthobiologics we currently specialize in using platelet rich plasma (PRP) and bone marrow concentrate (BMC-stem cells) as our two primary orthobiologics. We also use other...
Common questions
- Who writes the Texas Orthobiologics blog?
- Every post is written by Don Buford, MD, a board-certified orthopedic surgeon in Dallas. Since 2008 he has directed the longest-running private training course in musculoskeletal ultrasound and orthobiologics, and has personally trained more than 2,500 physicians. Nothing here is ghostwritten or syndicated.
- Why does the blog write so much about FDA rules on stem cells?
- Because much of what is marketed as stem cell therapy in the United States is not FDA-approved for orthopedic use, including umbilical cord blood, amniotic fluid, Wharton's jelly and exosome products. These posts state what the FDA has actually said and cite the warning letters and guidance rather than paraphrasing them.
- Does the practice publish its own PRP and stem cell measurements?
- Yes. PRP and bone marrow stem cell concentrate (BMAC) are measured in-office with a hematology analyzer, and the bench-test results are published here, including head-to-head comparisons of commercial systems. Very few practices measure their own product at all, and fewer publish what they find.
- What does the Texas Orthobiologics blog cover?
- More than 350 posts on orthobiologics, PRP, bone marrow stem cells (BMAC) and orthopedic surgery, in two recurring formats: what the FDA does and does not permit for stem cell treatments, and what a treatment actually measures or costs.
